Nick Pope has been ruled out of the Clarets’ final game of the season and will undergo surgery next week.
The Clarets’ keeper had hoped to play at Sheffield United after missing Burnley’s last two games with a knee injury.
But Pope, 29, now misses the game and will be assessed following his operation to see whether he will be available for England in the European Championship finals, which start next month.
“Unfortunately, Nick is going to need a minor operation on his knee this week," Burnley manager Sean Dyche confirmed to BT Sport.
“That’s not ideal for him or us and possibly for the England team. We’ll wait and see.
“It’s nothing too serious, we don’t think, but it still needed doing.
“He was trying to get right for this game to give it a test but didn’t quite come through in training, so he and we have had to make a judgement call on that.
“It’s mainly down to him and he knows what he’s got to do. He’ll have that (the operation) done this week and hopefully it will settle down for a quick recovery.”
Will Norris will again deputise for Pope at Bramall Lane, where the Clarets will also be without captain Ben Mee, who is not risked with a groin injury, as they look to end the season with three successive away wins.