Tony Philliskirk’s side will be looking to build on their last outing the Professional Development League, where the youngsters ran out 4-0 winners away at Crewe.
The Clarets who remain unbeaten in 2019, after two wins and a draw, host Sheffield united in the U18 PDL.
Meanwhile, the Blades have not won a game in their opening three fixtures of the new year, after a draw and two defeats.
When the two sides met back in September, United took all three points in a 1-0 win at their training ground.
Striker Michael Fowler will be looking to continue his fine form, as the former-Sunderland forward has hit a brace in his last three games for the Clarets.
A win would see Philliskirk’s side move up to third, depending on Nottingham Forest’s result.
And the Clarets currently sit a place above United in fifth, who do have three games in hand over Burnley.
The match kicks off at 11:00am at the Barnfield Training Centre, report and reaction will be online shortly after the match.