Burnley sign off for a mini-break with a trip to the south coast to face a Brighton side still fighting on two fronts.
Albion's midweek FA Cup fourth round replay win at WBA earned them a home tie against Derby County.
But first they must look to halt the recent resurgence of Sean Dyche's side who, following their FA Cup exit at Manchester City - which leaves them with a blank weekend next week - hope to extend their unbeaten league run this calendar year.
Indeed, after improving their position since the turn of the year, the Clarets have the incentive of knowing they can bridge the gap to the 13th place Seagulls and go level on points with an Amex victory.
Burnley boss Sean Dyche said: "The last run of six league games has shown a more consistent level of our identity, with performances and points. It could’ve been more, but some of that is outside of our control. The mentality was there, but it’s grown and it carries on doing so."
Brighton, meanwhile, are still in search of their first home win of 2019, after winning just one of their last five Premier League games, albeit with an impressive win away at Bournemouth.
Burnley should have wide men Johann Berg Gudmundsson and Robbie Brady both available again, following their return to action in last weekend's home draw with Southampton. Steven Defour is likely to miss out, along with Matt Lowton.
Brighton made 10 changes to the side for the FA Cup win at the Hawthorns, so wholesale changes are expected. Jose Izquierdo (knee) is likely to miss out as he recovers from injury and a late check will be made on the fitness of Dale Stephens.
Albion striker Florin Andone has been charged with violent conduct following their FA Cup win in midweek, leaving him at risk of a three-match ban.
Burnley are unbeaten in the last six league games and three on the road, including back-to-back away draws at Watford and Manchester United following the win at Huddersfield Town that kick-started the year.
Brighton, meanwhile, have won just one of their past 10 Premier League games, drawing three and losing six, and are winless in their five top-flight matches in 2019.
Earlier on this season, the two teams battled out a tough game at Turf Moor, won 1-0 by the Clarets, through a James Tarkowski goal.
Brighton manager Chris Hughton said: “I’m expecting a tight game, because generally that’s what it has been.
"Even the home games against Burnley, the levels of the two clubs and the two teams have been relatively similar over the last seasons.
“They, of course, had an outstanding season last season and that is testament to them, certainly with the budgets and what they have as regards the amount of players in the squad.
“So I expect a hard-fought game and with the fact we are at home, you hope to take advantage of that.
“Our home form has been good and we are on the back of a very good performance against Watford (0-0), but we expect a very tough game.”
The Clarets can set a club record of seven unbeaten Premier League games if they avoid defeat at The Amex Stadium.
Burnley remain unbeaten against Brighton and Hove Albion in the top flight, winning two and drawing the other of their three previous meetings.
Burnley ended a 67-game wait for a Premier League penalty against Southampton, with Ashley Barnes winning and converting their first spot-kick in the top flight since April 2017.
Brighton could fail to score in three consecutive top-flight home matches for the first time in their history.
Albion are winless in their last six games against the Clarets, although five of those matches were draws - a sequence which ended with Burnley's 1-0 win at Turf Moor earlier this season.
Glenn Murray is one short of 100 league goals for Brighton, across two spells at the club.
Ones to Watch
Ashley Barnes is top scorer for the Clarets, with seven goals in all competitions, while Glenn Murray tops the scoring charts for Brighton with 10 in the Premier League and two in the FA Cup.
Saturday 5:30pm (live on BT Sport).