Jon Walters is facing a further spell on the sidelines after under-going minor knee surgery.
The Clarets’ striker is recovering from an operation to repair slight cartilage damage and is expected to be out of action for around eight weeks.
“Jon Walters has had a minor tidy-up in his knee,” confirmed manager Sean Dyche.
“There was a very small split in the cartilage. It was annoying him, so the decision was made, from himself as well, because he’s old and wise enough, to get that tidied up.
“At his age he knows when it’s right or wrong, so he and the surgeon decided it was best to do it.”
The luckless Walters has made just one start – and four appearances from the bench - since joining Burnley from Stoke City last summer.
The Republic of Ireland international, 34, recently returned to the squad after around three months out with a knee injury but has seen his hopes of a more sustained comeback put on hold as he looks to get to the bottom of the problem.
Dyche added: “With good management we felt Jon would be okay, but unfortunately he has missed a lot of time and continues to do so.
“It is one of those things sometimes. Everyone wants him to be fit and he wants to be fit, but that’s the way it goes.”
The Clarets will also be without striker Chris Wood for Saturday’s visit of Manchester United as the New Zealand international – despite making good progress – is not yet ready to return from a knee injury.
Left-back Stephen Ward is in the same position, although Dyche’s squad should be strengthened by the return of Scott Arfield after two games out with a hamstring injury.
“Scott has every chance of getting back involved,” added the boss, who confirmed that club captain Tom Heaton is making significant strides in his recovery from shoulder surgery but not yet in full training with the first team.
“Tom is back working with Billy Mercer, not with the team, and doing all the things goallies do.
“He’s not quite in training yet, but he’s back working with Billy – diving, stretching etc.”