The Clarets return to Premier League action with a second trip to Manchester in four days as they try to become the ones to apply the brakes to the United bandwagon.
The Reds have been revived since former striker and ‘super-sub’ Ole Gunnar Solksjaer took control in mid-December.
With ex-Claret and former number two to Sir Alex Ferguson, Mike Phelan, at his side and that of first-team coach Michael Carrick, Solksjaer has seemingly changed the mood that was prevalent under former manager Jose Mourinho.
The players have responded to a change of regime and helped Solskjaer produce eight successive wins to enhance the claims of the 45-year-old to secure the managerial post on a permanent basis.
United are still in the Champions League, the FA Cup and back in contention for a top-four finish as they look to keep their winning streak going.
But the Clarets have proved themselves no pushover at Old Trafford in recent times, drawing 0-0 at United two seasons ago and then leading 2-0 there on Boxing Day last year before being pegged back right at the death to leave with a point.
A 5-0 FA Cup exit at Manchester City last Saturday should have no bearing on Tuesday night’s trip, with the Clarets’ focus purely back on Premier League points.
Taking 10 from the last 12 available has revived the Clarets’ campaign and lifted them clear of the bottom three.
And while Sean Dyche doesn’t under-estimate the size of the task facing his side, he insists ending United’s charge is no forlorn hope for his own in-form team.
“Performance is the king, yet again,” said the Burnley boss, who made seven changes to his starting line-up at City to keep legs fresh for Old Trafford.
“That's what you're looking for. I do think there always is that little bit of apprehension from a team, there has to be, because of the power of some of these clubs.
“Equally, it brings that expected performance because Manchester United at home will be clear favourites, they've won all these games on the trot.
“In balance we go there with a little bit of freedom because all eyes are on them, there's expectation on them and once again we're the big underdogs.
“It's just the way it is when you're playing these teams and they're going well. It's a tougher challenge, but it's not an impossible challenge.”
The Clarets will be back to something more like their recent Premier League line-up after ringing the changes for last Saturday’s FA Cup exit at Manchester City.
However, former Manchester United defender Phil Bardsley faces a fitness check with fellow right-back Matt Lowton still out.
Another ex-United man Robbie Brady is a doubt with a groin injury sustained at City but winger Johann Berg Gudmundsson is in contention for a possible return.
United are close to full strength with defender Chris Smalling in contention to start his first game under Ole Gunnar Solksjaer after recovering from injury.
However,Marcos Rojo and Marouane Fellaini are still sidelined.
The Clarets saw their five-match unbeaten run ended by a 5-0 defeat to Manchester City last the weekend.
But Sean Dyche’s men haven’t lost in the Premier League since Boxing Day and have taken four points from their last two away games.
The Clarets have drawn on their last two visits to Old Trafford.
Steven Defour scored a stunning free-kick in last season's 2-2 draw
Manchester United have a flawless record since Ole Gunnar Solksjaer replaced Jose Mourinho as acting manager in December.
Six of his eight wins have come in the Premier League, including three at home.
United’s improved form, which has brought them 22 goals under their former striker, has lifted them to sixth in the table, three points behind fourth-placed Chelsea.
Manchester United’s acting manager Ole Gunnar Solskjaer: “The results they’ve had and performances they’ve had says that (Burnley have turned a corner).
United old boys Mike Phelan and Michael Carrick are playing their part
“We know we’re up against a team that’s gonna come here and fight for three points as every single team in the Premier League will.
“They’ll cause you different problems, the physicality, the front two. We’ve got to be ready for them, but we’ve turned the corner ourselves. We looked really good against Arsenal defensively, we defended the box really well and that’s gonna be important against Burnley.”
The Clarets haven’t won at Old Trafford since 1962 but were only denied a first win in 19 attempts by an injury-time strike from Jesse Lingard last season.
Burnley boss Sean Dyche has never lost a Premier League on a Tuesday – a record covering five matches.
Manchester United’s acting boss Ole Gunnar Solksjaer is aiming to become the first manager to start a Premier League reign with seven straight wins.
United have had seven penalties in the Premier League this season – the most. The Clarets are yet to get one and didn’t get one last season either with their wait now extending to 66 games.
Prior to the game, the fan group Munich58 will stage an event to remember the victims of that tragedy.
Details are here (https://munich58.co.uk/2019-anniversary-commemorations-at-old-trafford/) and any Burnley fans who want to pay their respects will be welcome.