Goals from Charlie Austin, Ross Wallace and Marvin Bartley made it a night of derby delight for the Clarets as they secured a second home win of the season in impressive style.
An outstanding first-half performance laid the foundations for a fourth win in six Championships games to lift Burnley into mid-table.
Austin's ninth goal of the season paved the way, before a thundering free-kick from Wallace effectively sunk the Seasiders, whose winless run at Turf Moor stretched to six matches.
Blackpool's last success came 13 years ago and their luck was never likely to change, despite an improved second-half showing.
A much more solid defensive performance from Eddie Howe's men kept the visitors at bay until injury time, by which time Bartley had put the Clarets out of sight with his first goal for the club as Burnley gave their fluctuating campaign another timely shot in the arm.
Having started with the side that finished last Saturday's win at Coventry, the Clarets were forced into an early change as Brian Easton was forced off after getting a bang on the hip.
Charlie Austin heads the Clarets in front
That meant a re-shuffle with Ben Mee moving across to left-back with Andre Amougou coming off the bench to plug the gap in the centre of the defence.
And in an uncertain start, the Clarets could have gone behind as Jonjo Shelvey mis-kicked in front of goal from Tom Ince's low cross after Easton had been left on the floor.
However, the momentum quickly swung Burnley's way when Austin chased down a Wallace pass and forced Ian Evatt into a mistake.
From Austin's square ball Craig Cathcart was only inches away from putting the ball into his own net and when Wallace delivered the resulting corner, Jay Rodriguez mis-cued from a decent sight of goal.
Burnley weren't about to let Blackpool off the hook, though, and cranked up the pressure before going in front.
This time Wallace played a short corner with Junior Stanislas and when Stanislas delivered a superb near-post cross, the predatory Austin hurled himself at the ball to power a header into the roof of the net.
Ross Wallace makes it 2-0
Chris McCann then intercepted a pass from Shelvey and charged forward to blast an effort over the bar as Blackpool were left rocking at the back.
Stephen Crainey was probably relieved to get just a yellow card when he used an arm to block the ball and stop Austin's run on goal but the real punishment was delivered by Wallace as he made it 2-0.
The former Preston winger is no stranger to these derbies and struck his free-kick like he meant it as a stunning left-footed strike from 20 yards left Matt Gilks rooted to the spot as the ball flew into the top corner with half an hour gone.
Another dangerous cross from Stanislas then had Evatt at full stretch to head away from Austin and with Shelvey also going into the book for a late challenge on Mee, the Seasiders must have been glad to have reached the sanctuary of the dressing room at half time without further damage.
And whatever Ian Holloway said in there appeared to have some effect as Blackpool looked a different side after the break as they forced Burnley onto the back foot.
It was becoming a rearguard action from the Clarets, although Lee Grant was forced into only one meaningful save as he pushed a Brett Ormerod shot into the side netting as the veteran striker broke from half-way.
Burnley needed to relieve the pressure and with 67 minutes gone they had the chance from another Wallace free-kick which picked out Amougou for a stooping header which he couldn't direct on target.
With the Clarets having seemingly drawn the visitors' sting, Holloway played his final hand with a triple substitution with just over a quarter of an hour to go.
And it almost paid instant dividends, a flick from Lomano LuaLua releasing Callum McManaman for a run on goal which was only interrupted by an excellent covering tackle from the impressive David Edgar.
McManaman then tested Grant with a low drive which the keeper did well to parry away at full stretch before Burnley finally put the result beyond doubt with a third goal 11 minutes from time.
Marvin Bartley is up and running with his first goal
The Clarets had failed to make the most of a couple of opportunities to break but this time got it right as Austin got behind the defence before pulling the ball back for Bartley to side-foot home.
Another timely intervention from Edgar at the other end denied McManaman again and a good day could have got even better had Austin converted a simple chance from close range from McCann's perfect square pass with seven minutes to go.
Instead, the Clarets blotted their copybook slightly deep into injury time when Edgar's only slip of the night allowed Shelvey to fire home and dash hopes of a first clean sheet at Turf Moor since the start of March.
Burnley: Grant, Trippier, Easton (Amougou 9), Mee, Edgar, Bartley, McCann, Wallace (Marney 88), Rodriguez, Austin, Stanislas (Treacy 75). Subs: Hines, Stewart.
Blackpool: Gilks, Crainey, Southern, Evatt, Baptiste, Cathcart, Ferguson, Ince (McManaman 73), Phillips (LuaLua 73), Ormerod (Bogdanovic 73), Shelvey. Subs: Eardley, Howard.
Booked: Crainey28, Shelvey 40
Referee: Michael Oliver
The winning feeling